**3:45 - 4:15** :
Gurarie, David (Mathematics, Case Western Res University)

-Title: ** Immune regulation of malaria infection: model
calibration and Agent-Based Communities**

-Abstract:

The talk will outline basic biology of malaria infection
within host, and develop mathematical models that account for
parasite growth and its immune regulation. We shall discuss
how such models can be calibrated using malaria-therapy data,
and present some recent results.
Our calibrated in-host model can serve as a building block
for Agent-based Communities (ABC). We shall demonstrate a
few examples of such ABC, and look at the effect of
transmission intensity on the resulting patterns of parasitemia.
Our long-term goal is to apply 'agent-based' methodology to
study parasite transmission and control in realistic environment,
as an alternative to the standard population-based SIR
approach (Ross-Macdonald).

**4:15 - 4:45** :
Spagnuolo, Anna
(Mathematics, Oakland University)

-Title: ** A Mathematical Model for Vibrio Cholera
Colonization in the Human Intestine**

-Abstract:
* Vibrio cholera* is a strict human pathogen that causes
pandemic cholera. It is an old-world pathogen that has
re-emerged as a new threat since the early 1990s.
* V. cholera* colonizes the upper, small intestine where
it produces a toxin that leads to the watery diarrhea,
characterizing the disease. Colonization dynamics of
the bacteria are largely unknown. Although a large
initial infectious dose is required for infection, data
suggests that only a smaller sub-population colonizes
a portion of the small bowel leading to the disease.
There are many barriers to colonization in the
intestines. In this talk, I will elaborate on the
dynamics of * V. cholera* infection by describing a
mathematical model that governs the colonization process
for the bacterial dynamics.